Sara Rodriguez, a 73-year-old Hispanic female, has been experiencing difficulty getting her BP to goal even though you recently increased her dose of hydrochlorothiazide to 50 mg/d. Lately, Ms. Rodriguez reports that her ankles have been swelling “more than normal,” she’s having some trouble sleeping through the night, and she has to urinate a lot even if she hasn’t been drinking liquids much throughout the day. You diagnose CKD after the laboratory results show her estimated glomerular filtration rate (eGFR) to be 37 mL/min/1.73 m2.

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